Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations
نویسندگان
چکیده
منابع مشابه
Protein Conformation and Supercharging with DMSO from Aqueous Solution
The efficacy of dimethyl sulfoxide (DMSO) as a supercharging reagent for protein ions formed by electrospray ionization from aqueous solution and the mechanism for supercharging were investigated. Addition of small amounts of DMSO to aqueous solutions containing hen egg white lysozyme or equine myoglobin results in a lowering of charge, whereas a significant increase in charge occurs at higher ...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2011
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-011-0301-y